Studies comparing the efficacy of Uterine Fibroid Embolization (UFE) and myomectomy reveal important trade-offs regarding Long-Term Outcomes. UFE offers the advantage of a faster initial recovery and is a non-surgical option, with most patients reporting significant symptom relief within the first year as fibroids shrink. However, long-term observational data, particularly from large-scale comparative trials, indicate that UFE is associated with a higher likelihood of requiring a subsequent procedure, including repeat UFE or eventual hysterectomy, five years post-treatment.

Myomectomy, which physically removes the existing fibroid masses, is often associated with a lower rate of subsequent intervention for persistent symptoms. While it requires a longer recovery period and carries the risk of adhesion formation, its capacity for definitive symptom control of the existing masses is generally sustained over time. These results suggest that while UFE is highly effective and less invasive in the short-term, myomectomy provides a more durable solution for many patients, highlighting the need for careful counseling on the longevity of symptom relief.

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